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This paper studied the degradation of cholesterol and three plant sterols during a 360 min heating treatment (180ºC). application/pdf <> <> endobj endstream 23 cells used as the inoculum in UHT milk rather than in an\ud artificial medium, prior to determination of cholesterol degradation.\ud The cholesterol degrading system of R. equi No. -3.112 0 Td 249 0 obj 498 0 obj <> BT <> ( )Tj endobj 2016-02-09T17:57:47+11:00 467 0 obj It was suggested that hypolipidemic activity of okra was mediated most likely by upregulation of cholesterol degradation through CYP7A1 and by inhibition of lipogenesis through SREBP1c and FAS. 405 0 obj (When a correction for this article is posted)Tj Cholesterol increases the risk of aggressive pros- <> endobj Acrobat 4.0 Import Plug-in for Windows 449 0 obj Direct visualization with fluorescence microscopy The studied strains degrade cholesterol by different mechanisms and may suggest a new possibility for the mechanism underlying cholesterol degradation by LAB. DOI: 10.1038/embor.2011.205 Corpus ID: 8170940. endobj <> Degradation to primary bile acids represents the most relevant mechanism of irreversible elimination of cholesterol from the body, thus playing a key role in hepatic and systemic cholesterol homeostasis. <> (Access the most updated version of this article at )Tj <> DOI: 10.1074/jbc.M113.515890 Corpus ID: 10279237. endobj Cholesterol is an extremely important biological molecule that has roles in membrane structure as well as being a precursor for the synthesis of the steroid hormones, the bile acids, and vitamin D.Both dietary cholesterol, and that synthesized de novo, are transported through the circulation in lipoprotein particles. (\240 )Tj 396 0 obj 495 0 obj 493 0 obj 514 DEGRADATION OF CHOLESTEROL diluted to 10 ml. endobj endobj endobj 10 0 0 10 89 413.99994 Tm 487 0 obj Phytosterols and cholesterol share a similar chemical structure, and undergo oxidation during food processing and storage. /T1_0 1 Tf 10 0 0 10 120.11996 399 Tm FK�`��I.4�3`>��nX�s�ƎQ&��"X.8�V'�?5��`d��"k�^z�&��[Z��0By ��Gc�HP9��AV[�qҲ�MN�gMC��7��j�4o�|��+ �E� ��ug��!��G��~^��C:�� 214 0 obj endobj [384 0 R 385 0 R 386 0 R 387 0 R 388 0 R 389 0 R 390 0 R 391 0 R 392 0 R 393 0 R 394 0 R 395 0 R] ... synthesis and degradation of the enzyme. endobj (\225\240 )Tj Normal cholesterol levels are strictly maintained by de novo synthesis and degradation and cells can sense their level of cholesterol through the membrane-bound sterol regulatory element-binding protein (SREBP) (Brown and Goldstein, 1997). 402 0 obj /T1_3 1 Tf [321 0 R 322 0 R 323 0 R 324 0 R 325 0 R 326 0 R 327 0 R 328 0 R 329 0 R 330 0 R 331 0 R 332 0 R 333 0 R 334 0 R 335 0 R 336 0 R 337 0 R 338 0 R] endobj 455 0 obj endobj 10 0 0 10 109 368.99994 Tm Okra raw and fractionated polysaccharide showed strong bile acid binding capacity in vitro , which may contribute to the hypolipidemic activity observed. endobj <> endobj [506 0 R] [539 0 R] Degradation of EGFR through APMAP Siyuan Jiang1, Xuetong Wang1, Dalong Song2, XiaoJun Liu1,Yinmin Gu1, ... High cholesterol inhibits EGFR internalization by promoting the competitive binding of APMAP to EPS15R, which in turn activates ERK1/2 to promote epithelial-to-mesenchymal transition. endobj <> <> 223 0 obj <> <> 453 0 obj endobj endobj <> BT (When this article is cited)Tj The subjects were divided into two groups (A and B), each group receving the butter containing diet (B) during one period and the safflower oil containing diet (S) during another 2004). <> /T1_3 1 Tf /T1_0 1 Tf 0 g endobj (alerts)Tj <> 0 g 202 0 obj 462 0 obj 473 0 obj <> 466 0 obj <> endobj Sterol regulatory element-binding proteins (SREBPs) are transcription factors that control production of cholesterol and other lipids. (Click here)Tj endobj endobj 492 0 obj Examination of cholesterol utilization dur-ing mycobacterial growth using the coupled cholesterol- (Alerts: )Tj endobj endobj 213 0 obj '��~��Z�`Ϩ��,��MSdF��$i��SI9�GM@\}/��coz�RjO]b�Đt�@a�[Um��P�O��O�:D��iH ��Lq�wI��b��AY��S+@`v#%@��q�� 79R�!�5F��ȉgy�� xȃI9^�H,�)8>/�%*K�=�Eq2�Y��d��Ve8��^T��(�hŇ��\��/e��o��Zy. endobj Both the isolates S. marcescens W1 and B. pumilus W8 showed increased cholesterol degradation with increasing concentration of cholesterol from 0.5 up to 1.0 g/L, while further increase in concentration of cholesterol reduced the degradation (Figure 2(b)).Maximum degradation of cholesterol (54.6% and 57.6%) was observed with Serratia marcescens W1 and … 221 0 obj 208 0 obj F��L�&֖��|��nή� D�w�p�2�1ѥ�m:�ݤ�e��7A��&�>4L��x�a��:ǹ�=*�x3#�Ǌ�]%r%��c�?7��6�u�Ij~�| Υu�;�]�H��Y>�Pq-1��'�z�,7λ5�<8�I{@�"F~�$C��ιo#S3��R�{[s�p z\��k��x��3"l�$�as�=��E`$Ȩ�7EՖ �6��W��>�/a�ĕ��KR� 4.44499 1 Td [307 0 R 308 0 R 309 0 R 310 0 R 311 0 R 312 0 R 313 0 R 314 0 R 315 0 R 316 0 R 317 0 R 318 0 R 319 0 R 320 0 R] [250 0 R 251 0 R 252 0 R 253 0 R 254 0 R 255 0 R 256 0 R 257 0 R 258 0 R] -5.49997 0 Td ( to choose from all of JBC's e-mail)Tj endstream 205 0 obj endobj endobj 0 0 1 rg [291 0 R 292 0 R 293 0 R 294 0 R 295 0 R 296 0 R 297 0 R 298 0 R 299 0 R 300 0 R 301 0 R 302 0 R 303 0 R 304 0 R 305 0 R 306 0 R] <>stream endobj BT 4-cholesten-3-one was detected as a degradation product of cholesterol by Leuconostoc mesenteroides GMK03. Cholesterol and phytosterols can suffer oxidation under heating conditions to give Sterol Oxidation Products (SOPs), known by their toxic effects. endobj 469 0 obj uuid:a6809487-1dd1-11b2-0a00-530927bdd100 endobj <> 17 0 obj endobj endobj Maximum cholesterol degradation by the isolates occurred in the cholesterol medium (Medium-A), where cholesterol (1 g/L) was supplemented with as a sole carbon source for 6 d. Approx, 65-80% of the cholesterol was degraded by the isolates (Table 2). 458 0 obj S <> 500 0 obj endobj 390 0 obj ET 10 0 0 10 154.01996 492 Tm BT ET endobj <> 536 0 obj endobj Keywords: 7-dehydrocholesterol, cholesterol, DHCR7, degradation, vitamin D ABSTRACT . -18.61797 0 Td -10.78099 0 Td We present in this study the potential of Gordonia cholesterolivorans to use cholesterol as the only car-bon and energy source for … with CHCL, and read at 390 rnp against a reagent blank. L-a-distearoyl phosphatidylcholine; CH,cholesterol. 206 0 obj f �-��2DaV:��`P�pt�|5[&�ޟ��' ~��%.�_�� T�� /=�M�j1 Nֺ��^Ž\��K��a��c�-A�W Ae�5W�2�,V��W!A�k�ʐA�z��ǖ��0D��T, Cholesterol-Mediated Degradation of 7-Dehydrocholesterol Reductase Switches the Balance from Cholesterol to Vitamin D Synthesis. endobj 19.67698 1 Td <> (http://www.jbc.org/)Tj <> cholesterol content.21 Therefore, GW3965, an LXR agonist, can induce cellular response to cholesterol accumulation in the cells and was used to examine effects of cholesterol accumulation on the degradation of csABCA1. 490 0 obj <> (\240)Tj 0 1 TD *s�Ar��b39��A�i=�}��L�Ok�a��P�+Fr�t��v-��)+��$a�4 -19.67698 0 Td With dialyzed preparations, it was possible to follow cholestenone for- mation from cholesterol by measuring the increase in absorption at 240 rnp in 90 per cent ethanol extracts. <> Contain 24 carbon atoms, 2 or 3 OH groups in steroid nucleus & a side chain ending in carboxyl group. 454 0 obj endobj 210 0 obj /T1_0 1 Tf <> 401 0 obj 224 0 obj <> <>/ProcSet[/PDF/Text/ImageB]/XObject<>>>/Rotate 0/Type/Page>> <>/ProcSet[/PDF/Text]>>/Type/Page>> BT <>/ProcSet[/PDF/Text/ImageB]/XObject<>>>/Rotate 0/Type/Page>> <> [259 0 R 259 0 R 259 0 R 259 0 R 259 0 R 259 0 R 260 0 R 261 0 R 262 0 R 263 0 R 264 0 R 265 0 R 266 0 R 267 0 R] 471 0 obj 200 0 obj 0 0 1 rg <>stream <>/ProcSet[/PDF/Text/ImageB]/XObject<>>>/Rotate 0/Type/Page>> <>/Metadata 502 0 R/Pages 2 0 R/StructTreeRoot 3 0 R/Type/Catalog>> Full text Full text is available as a scanned copy of the original print version. 501 0 obj endobj 211 0 obj Cholesterol accumulation and degradation by mycobacteria Three different experimental approaches were used to de-termine cholesterol utilization by mycobacteria, specifically colorimetric determination of cholesterol levels, TLC, and HPLC analysis. T* endobj <> … endobj 11.68699 1.00001 Td 89 468 m <> 19.52397 1 Td <> endobj The isolated microorganisms were grown in the );�aa(B��L9��n�Jb��?vG��־)'_�j�R�?�l毕��ywe��h>��%�e��!��/��M��+�2�Rg��t~y|5��οv^e�L4��F91_��n��ǳ닳�pc�x/V��D#{��\ 459 0 obj endobj endobj 201 0 obj 475 0 obj 407 0 obj 4030 Thepublication costs of this article weredefrayed in part by page chargepayment. 474 0 obj endobj endobj uuid:f2996e4c-1dd1-11b2-0a00-ad09271d5700 Degradation of Cationized Low Density Lipoprotein and Regulation of Cholesterol Metabolism in Homozygous Familial Hypercholesterolemia Fibroblasts 0 g <> [339 0 R 340 0 R 341 0 R 342 0 R 343 0 R 344 0 R 345 0 R 346 0 R 347 0 R 348 0 R 349 0 R 350 0 R 351 0 R 352 0 R 353 0 R 354 0 R 355 0 R 356 0 R] <> endobj /T1_0 1 Tf <> endobj The bile acids are synthesized in the liver from cholesterol. 408 0 obj The bacterial degradation of cholesterol has been known to occur by a cholesterol oxidase (cholesterol : oxygen oxidoreductase, EC 1.1.3.6), the enzyme which catalyses the oxidation of cholesterol to 4‐cholesten‐3‐one, along with the reduction … <>/ProcSet[/PDF/Text/ImageB]/XObject<>>>/Rotate 0/Type/Page>> 3.3.2. endobj ET endobj (http://www.jbc.org/content/206/2/511.citation.full.h)Tj 0 0 1 rg the five subjects weighed 72.3, 66.8, 102.3, 68.2, and 65.7 kg, respectively, the total dietary intake was adjusted for each individual to maintain a constant (± 1.0 kg) body weight during the course of the experiment. BT When cholesterol levels are low, Scap escorts SREBPs from the ER to the Golgi where proteolytic cleavage releases the transcription factor … %PDF-1.5 %�� <> ET endobj endobj -0.22452 1.00001 Td endobj ( )Tj 212 0 obj [369 0 R 370 0 R 371 0 R 372 0 R 373 0 R 374 0 R 375 0 R 376 0 R 377 0 R 378 0 R 379 0 R 380 0 R 381 0 R 382 0 R 383 0 R] 489 0 obj In these preparations cholesterol degradation was further enhanced by\ud growth of R. equi No. (STUDIES ON THE MICROBIOLOGICAL)Tj endobj <> /T1_0 1 Tf 465 0 obj ՝/�I��QI��`��n�.��&��[b��\b]��OB^�6��ۙB4��m��S�Q$�jWP�w&��[�~t��S�o? <> 2020-12-27T13:19:36-08:00 STABILITY AND DEGRADATION STUDIES OF CHOLESTEROL-LOWERING STATIN DRUGS MAŁGORZATA PIECHA DISSERTATION Mentor: Prof. dr. Polonca Trebše Nova Gorica, 2009 . <> endobj endobj ( by guest on December 27, 2020)Tj (accessed free at)Tj [492 0 R 493 0 R 494 0 R 495 0 R 496 0 R 497 0 R 498 0 R] endobj Cellular cholesterol levels are also modulated by a cycle of cholesterol esterification by acyl- CoA : cholesterol acyltransferase (ACAT) and hydrolysis of the cholesteryl esters, and by cholesterol metabolism to … [424 0 R 425 0 R 426 0 R 427 0 R 428 0 R 429 0 R 430 0 R 234 0 R] 3 0 obj 461 0 obj 1 0 obj 2003-02-19T11:44:14+05:30 216 0 obj 282 0 obj (This article cites 0 references, 0 of which can be)Tj <> <> 12 0 0 12 143.99991 509.99991 Tm <> 7- <> Introduction to Cholesterol Metabolism. endobj <>stream endobj <> (J. Biol. endobj T* <> endobj Cellular Cholesterol Regulates Ubiquitination and Degradation of the Cholesterol Export Proteins ABCA1 and ABCG1* @article{Hsieh2014CellularCR, title={Cellular Cholesterol Regulates Ubiquitination and Degradation of the Cholesterol Export Proteins ABCA1 and ABCG1*}, author={V. Hsieh and Mi-Jurng Kim and I. Gelissen and A. <> (1954, 206:511-523. <>/MediaBox[0 0 609.84 792.12]/Parent 534 0 R/Resources<>/Font<>/ProcSet[/PDF/Text]>>/StructParents 21/Tabs/S/Type/Page>> endobj 472 0 obj 204 0 obj endobj ET /T1_3 1 Tf 494 0 obj 464 0 obj endobj BT endobj endobj Free fulltext PDF articles from hundreds of disciplines, all in one place Novel Inhibitors of Cholesterol Degradation in Mycobacterium tuberculosis Reveal How the Bacterium’s Metabolism Is Constrained by the Intracellular Environment (pdf) | Paperity (Downloaded from )Tj <>/ProcSet[/PDF/Text/ImageB]/XObject<>>>/Rotate 0/Type/Page>> 203 0 obj <> 348 0 obj Substrate Concentration. [443 0 R 444 0 R 445 0 R 446 0 R 237 0 R] endobj endobj ��e��8h��c��&��@�5��y�;,�toQ��q��v�8��[�&�,2��)�)�F6R�ֲ��i�`0�]��2��)+��т�� e�);Nb|��y0��. BT endobj 222 0 obj 0 g 215 0 obj <> (DEGRADATION OF CHOLESTEROL)Tj endobj ET S. C. §1734solely toindicate Downloaded by guest on … Many types of cholesterol oxidation products have been found in different food products and their negative biological activities have been extensively reviewed (Gill et al., 2008, Otaegui-Arrazola et al., 2010, Paniangvait et al., 1995). endobj 447 0 obj 217 0 obj application/pdf 488 0 obj /T1_2 1 Tf endobj 220 0 obj [284 0 R 285 0 R 286 0 R 287 0 R 288 0 R 289 0 R 290 0 R] -3.985 1 Td <>stream Cholesterol-Mediated Degradation of 7-Dehydrocholesterol Reductase Switches the Balance from Cholesterol to Vitamin D Synthesis HepG2 cells and HuH-7 cells both originated from a human hepatoma and endogenously express ABCA1. Microsoft® Word 2010 470 0 obj [225 0 R 226 0 R 227 0 R 228 0 R 229 0 R 238 0 R 239 0 R 240 0 R 241 0 R 242 0 R 243 0 R 244 0 R 245 0 R 246 0 R 247 0 R 248 0 R 249 0 R] /T1_3 1 Tf endobj 468 0 obj endobj (\225\240 )Tj [438 0 R 439 0 R 440 0 R 441 0 R 442 0 R 236 0 R] In this report, our objective was to develop an integral mathematic model for studying the thermal degradation or oxidation of quercetin in the presence and absence of cholesterol. (Thressa C. Stadtman, Amelia Cherkes and)Tj <> 216 0 obj [420 0 R 421 0 R 422 0 R 423 0 R 233 0 R] 400 0 obj -4.44499 0 Td /T1_1 1 Tf <> -6.502 0 Td [403 0 R 404 0 R 405 0 R 406 0 R 407 0 R 408 0 R 409 0 R 410 0 R 230 0 R] The formation and further degradation of SOPs was also analyzed by GC-MS. 209 0 obj 207 0 obj 451 0 obj 499 0 obj 505 0 obj In endoplasmic reticulum (ER) membranes, SREBPs form complexes with Scap, a cholesterol-sensing membrane protein. endobj 0 g PDF | On Jun 14, 2019, Fadhil Jawad Altu'ma published Cholesterol Metabolism | Find, read and cite all the research you need on ResearchGate. <> <> Chem.\240)Tj Hence, enzymes involved in its synthesis possess many layers of regulation to achieve balanced cholesterol levels. endstream 0 0 1 rg 448 0 obj endobj 0 1.00001 TD ACKNOWLEDGEMENTS The se last p ages of a PhD thesis a re usually the most widely re ad pages of the entire publication. 0 -8 8 0 380 314.10809 Tm 2020-12-27T13:19:22-08:00 150 0 obj Brain cholesterol is catabolized to 24S-hydroxycholesterol (24S-OHC) by the neuron-speciﬁc 0 g endobj <> <> Cholesterol accelerated the proteasomal degradation of SM which required the N-terminal domain, partially conserved in vertebrates but not in lower organisms. Cholesterol (50%) is converted to bile acids (excreted in feces), serves as a precursor for the synthesis of steroid hormones, vitamin D, coprostanol & cholestanol. 10 0 0 10 89 343.99997 Tm Mechanistic implications for LDL receptor degradation from the PCSK9/LDLR structure at neutral pH @article{Surdo2011MechanisticIF, title={Mechanistic implications for LDL receptor degradation from the PCSK9/LDLR structure at neutral pH}, author={Paola Lo Surdo and Matthew J. Bottomley and A. Calzetta and Ethan C Settembre and A. 183 0 obj <>stream H��W[o۸~ϯࣵX˼SZ��Ӄ؞xq��M'��:��ߡ$�#�T�8yHb�3��Ofﶻ��厼y3{��-.o�+r1;��v��:�?�Wd��by�^�n7k��{r2��l>��J2�>Q��Z�rY��ɄI��X�5��ȵ�d�DN��,�O��L��l��3B��e�h�rE�g'�y&sJ�d�.Sdr�M5|��$�O��C&�ʐ�yFseJ�@�:��8�0P��sm��7y�� G��]�M�G�M+�'@��L7�R��Fm�.&��u�Z�n�R��-8��QXeL��hP�M�`e��4�p��_@�)��M�q�W�,S�P��L~D�d*�� QQZq@�Oƨ]�eSP�8{�Ycq6�5��l��^�և uuid:f2996e4f-1dd1-11b2-0a00-bf0000000000 During cholesterol degradation, three further intermediate compounds were identified by their characteristic mass spectrum, namely, 26-hydroxycholest-4-en-3-one (m/z 401), 26-hydroxycholesta-1,4-dien-3-one (m/z 399), and cholest-4-en-3-one-26-oic acid (m/z 415) in parallel to cholest-4-en-3-one. endobj endobj 469 0 obj endobj ET 0 0 m 10 0 0 10 89 278.99988 Tm endobj 0 0 1 rg <>/ProcSet[/PDF/Text/ImageB]/XObject<>>>/Rotate 0/Type/Page>> (\240 )Tj endobj 2020-12-27T13:19:22-08:00 Links to PubMed are also available for Selected References. Unlike HMGR, SM degradation is not mediated by Insig, 24,25-dihydrolanosterol, or side-chain oxysterols, but rather by cholesterol itself. 398 0 obj <> endobj endobj 450 0 obj [268 0 R 269 0 R 270 0 R 271 0 R 272 0 R 273 0 R 274 0 R] <> endobj thermal degradation of cholesterol were reduced greatly after incorporation of quercetin [17]. %PDF-1.4 %�� <> endobj ET mRNA stability, translation, enzyme phosphorylation and enzyme degradation. Cholesterol is detrimental to human health in excess, but is also essential for normal embryogenesis. 315 0 obj uuid:f282d8e4-1dd1-11b2-0a00-1e00c807b0ff 486 0 obj The maximum cholesterol degradation (about 90%) was obtained on the third day. degradation of cholesterol 1. ET Brown and C. … )Tj 496 0 obj <>/ProcSet[/PDF/Text/ImageB]/XObject<>>>/Rotate 0/Type/Page>> endobj /T1_0 1 Tf H��WkS�J��_��I�-��o�{/�6��wkK��W�P�_�3�L�r�&U�T==�8}�̟�yNx��? Cholesterol (from the Ancient Greek chole-() and stereos (solid), followed by the chemical suffix-ol for an alcohol) is an organic molecule.It is a sterol (or modified steroid), a type of lipid. endobj However, the degradation or oxidation of quercetin remained unknown. 397 0 obj 1.P.47 Degradation of pyrene-labeled cholesterol esters by lysosomal lipase in vitro and in vivo. BT 504 0 obj 457 0 obj <> 456 0 obj 468 0 obj -0.906 0 Td -0.906 0 Td endobj Under physiological conditions, approximately 300–400 mg of cholesterol are disposed of in the liver daily, through this pathway [3]. ( )Tj 312 468 l <> (tml#ref-list-1)Tj endobj brown lab endobj endobj endobj (Christian B. Anfinsen)Tj 5.49997 1 Td 535 0 obj 218 0 obj 502 0 obj 2020-12-27T13:19:36-08:00 463 0 obj /T1_3 1 Tf endobj 2 0 obj <> well documented (7, 9, 19, 27, 32, 33), but the degradation of cholesterol by a member of the genus Gordonia was reported only recently (8). <> <> endobj 219 0 obj endobj [411 0 R 412 0 R 413 0 R 414 0 R 231 0 R] ( )Tj endobj endobj 485 0 obj Cholesterol homeostasis is vital for proper cellular and systemic functions. Thisarticle mustthereforebeherebymarked"ad-vertisement"inaccordancewith 18U. 410 0 obj endobj endobj 502 0 obj [396 0 R 397 0 R 398 0 R 447 0 R 448 0 R 448 0 R 448 0 R 449 0 R 450 0 R 450 0 R 450 0 R 450 0 R 451 0 R 452 0 R 452 0 R 452 0 R 452 0 R 452 0 R 452 0 R 452 0 R 453 0 R 454 0 R 454 0 R 454 0 R 454 0 R 454 0 R 454 0 R 455 0 R 456 0 R 457 0 R 458 0 R 459 0 R 460 0 R 461 0 R 462 0 R 463 0 R 464 0 R 465 0 R 466 0 R 467 0 R 468 0 R 469 0 R 470 0 R 471 0 R 472 0 R 473 0 R 474 0 R 475 0 R 400 0 R 401 0 R 402 0 R] Cell Reports Report GRP94 Regulates Circulating Cholesterol Levels through Blockade of PCSK9-Induced LDLR Degradation Steve Poirier,1,2 Maya Mamarbachi,1 Wan-Ting Chen,3 Amy S. Lee,3 and Gaetan Mayer1,2,4,* 1Laboratory of Molecular Cell Biology, Montreal Heart Institute, Montre´al, QC H1T 1C8, Canada 2Department of Pharmacology, Faculty of Medicine, Universite ´de Montreal, Montreal, QC … (\240 )Tj [357 0 R 358 0 R 359 0 R 360 0 R 361 0 R 362 0 R 363 0 R 364 0 R 364 0 R 364 0 R 364 0 R 364 0 R 364 0 R 364 0 R 364 0 R 364 0 R 364 0 R 364 0 R 364 0 R 364 0 R 364 0 R 364 0 R 364 0 R 364 0 R 364 0 R 364 0 R 364 0 R 364 0 R 364 0 R 364 0 R 364 0 R 364 0 R 364 0 R 364 0 R 364 0 R 364 0 R 364 0 R 364 0 R 364 0 R 364 0 R 364 0 R 364 0 R 364 0 R 364 0 R 364 0 R 365 0 R 366 0 R 367 0 R 368 0 R] -7.55399 0 Td 491 0 obj 472 0 obj [275 0 R 276 0 R 277 0 R 277 0 R 277 0 R 277 0 R 277 0 R 277 0 R 277 0 R 277 0 R 277 0 R 277 0 R 277 0 R 277 0 R 277 0 R 277 0 R 278 0 R 279 0 R 280 0 R 281 0 R 282 0 R 283 0 R] 460 0 obj -7.88899 0 Td endobj Get a printable copy (PDF file) of the complete article (2.5M), or click on a page image below to browse page by page. (http://www.jbc.org/content/206/2/511.citation)Tj 0 0 1 rg ARTICLE Insig-mediated degradation of HMG CoA reductase stimulated by lanosterol, an intermediate in the synthesis of cholesterol Bao-Liang Song,1 Norman B. Javitt,2 and Russell A. DeBose-Boyd1,* 1Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 2Department of Pediatrics and Medicine, New York University School of Medicine, New York, … 452 0 obj 503 0 obj [415 0 R 416 0 R 417 0 R 418 0 R 419 0 R 232 0 R] [431 0 R 431 0 R 431 0 R 432 0 R 433 0 R 434 0 R 435 0 R 436 0 R 437 0 R 235 0 R] <>/ProcSet[/PDF/Text/ImageB]/XObject<>>>/Rotate 0/Type/Page>> endobj Acrobat 4.0 Capture Plug-in for Windows Microsoft® Word 2010 -0.66701 1 Td endobj <> 497 0 obj From cholesterol Sterol oxidation Products ( SOPs ), degradation of cholesterol pdf by their effects. Degradation, vitamin D ABSTRACT, enzyme phosphorylation and enzyme degradation studied strains cholesterol... 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Paper studied the degradation or oxidation of quercetin remained unknown new possibility for the mechanism cholesterol!

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